Effectiveness of Haemophilus influenzae type b conjugate vaccine on radiologically-confirmed pneumonia in young children in Pakistan.

Clicks: 270
ID: 39426
2013
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Popular

Ranked #29 of 37 articles by views in the journal of pediatrics

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
The effectiveness of Haemophilus influenzae type b (Hib) vaccine in preventing severe pneumonia in Asian children has been questioned, and many large Asian countries yet to introduce Hib conjugate vaccine in immunization programs. The primary objective of this study was to assess Hib conjugate vaccine effectiveness (VE) on radiologically-confirmed pneumonia in children born after introduction of Hib conjugate vaccine in Pakistan.A matched case-control study enrolled cases of radiologically-confirmed pneumonia in several hospitals serving low-income populations during 2009-2011. Cases were matched by age and season with 3 hospital and 5 neighborhood controls. Pneumonia was diagnosed using standardized World Health Organization criteria for chest radiograph interpretation. Matched OR were estimated for VE.A total of 1027 children with radiologically-confirmed pneumonia were enrolled; 975 cases, 2925 hospital controls, and 4875 neighborhood controls were analyzed. The coverage for 3 doses of diphtheria-tetanus-pertussis-hepatitis B-Hib conjugate vaccine was 13.7%, 18%, and 22.7% in cases, hospital controls and neighborhood controls, respectively. Estimated Hib VE for radiologically-confirmed pneumonia was 62% with 3 doses of vaccine using hospital controls and 70% using neighborhood controls.Hib conjugate vaccine prevented a significant fraction of radiologically-confirmed pneumonia in children in Pakistan. Maximizing impact on child survival needs improved immunization coverage.
Reference Key
khowaja2013effectivenessthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Khowaja, Asif Raza;Mohiuddin, Syed;Cohen, Adam L;Mirza, Waseem;Nadeem, Naila;Zuberi, Talha;Salam, Basit;Mubarak, Fatima;Rizvi, Bano;Husen, Yousuf;Pardhan, Khatidja;Khan, Khalid Mehmood A;Raza, Syed Jamal;Zuberi, Hassan Khalid;Mustafa, Sultan;Sheikh, Salma H;Nizamani, Akbar;Lohana, Heermani;Mulholland, Kim;Zell, Elizabeth;Hajjeh, Rana;Bosan, Altaf;Zaidi, Anita K M;, ;
Journal the journal of pediatrics
Year 2013
DOI
10.1016/j.jpeds.2013.03.034
URL
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.