Antibacterial, Antiproliferative, and Immunomodulatory Activity of Silver Nanoparticles Synthesized with Fucans from the Alga Dictyota mertensii

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ID: 39339
2017
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Abstract
In this study, we aimed to synthesize silver nanoparticles containing fucans from Dictyota mertensii (Martius) Kützing using an environmentally friendly method and to characterize their structure as well as antiproliferative, immunomodulatory, and antibacterial effects. Fucan-coated silver nanoparticles (FN) were characterized by Fourier-transform infrared analysis, dynamic light scattering, zeta potential, atomic force microscopy, energy dispersive X-ray spectroscopy, and inductively coupled plasma emission spectrometry. They were evaluated for their effect on cell viability, minimum inhibitory bactericidal concentration, and release of nitric oxide and cytokines. The FN were successfully synthesized using an environmentally friendly method. They were size-stable for 16 months, of a spherical shape, negative charge (−19.1 mV), and an average size of 103.3 ± 43 nm. They were able to inhibit the proliferation of the melanoma tumor cell line B16F10 (60%). In addition, they had immunomodulatory properties: they caused an up to 7000-fold increase in the release of nitric oxide and cytokines (IL-10; IL-6 and TNF-α) up to 7000 times. In addition, the FN showed inhibitory effect on Gram-positive and -negative bacteria, with MIC values of 50 µg/mL. Overall, the data showed that FN are nanoparticles with the potential to be used as antitumor, immunomodulatory, and antibacterial agents.
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fernandesnegreiros2017antibacterialnanomaterials Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Fernandes-Negreiros, Marília Medeiros;Machado, Raynara Iusk Araújo;Bezerra, Fabiana Lima;Melo, Maria Celeste Nunes;Alves, Monique Gabriela Chagas Faustino;Filgueira, Luciana Guimaraes Alves;Morgano, Marcelo Antonio;Trindade, Edvaldo Silva;Costa, Leandro Silva;Rocha, Hugo Alexandre Oliveira;
Journal Nanomaterials
Year 2017
DOI
DOI not found
URL
https://www.mdpi.com/2079-4991/8/1/6
Keywords Keywords not found

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