Ga-radiolabeled bombesin-conjugated to trimethyl chitosan-coated superparamagnetic nanoparticles for molecular imaging: preparation, characterization and biological evaluation.

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ID: 39303
2019
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Abstract
Nowadays, nanoparticles (NPs) have attracted much attention in biomedical imaging due to their unique magnetic and optical characteristics. Superparamagnetic iron oxide nanoparticles (SPIONs) are the prosperous group of NPs with the capability to apply as magnetic resonance imaging (MRI) contrast agents. Radiolabeling of targeted SPIONs with positron emitters can develop dual positron emission tomography (PET)/MRI agents to achieve better diagnosis of clinical conditions.In this work, ,,-trimethyl chitosan (TMC)-coated magnetic nanoparticles (MNPs) conjugated to -2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid (DOTA) as a radioisotope chelator and bombesin (BN) as a targeting peptide (DOTA-BN-TMC-MNPs) were prepared and validated using fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), thermogravimetric analysis (TGA), vibrating sample magnetometer (VSM), and powder X-ray diffraction (PXRD) tests. Final NPs were radiolabeled with gallium-68 (Ga) and evaluated in vitro and in vivo as a potential PET/MRI probe for breast cancer (BC) detection.The DOTA-BN-TMC-MNPs with a particle size between 20 and 30 nm were efficiently labeled with Ga (radiochemical purity higher than 98% using thin layer chromatography (TLC)). The radiolabeled NPs showed insignificant toxicity (>74% cell viability) and high affinity (IC=8.79 µg/mL) for the gastrin-releasing peptide (GRP)-avid BC T-47D cells using competitive binding assay against Tc-hydrazinonicotinamide (HYNIC)-gamma-aminobutyric acid (GABA)-BN (7-14). PET and MRI showed visible uptake of NPs by T-47D tumors in xenograft mouse models.Ga-DOTA-BN-TMC-MNPs could be a potential diagnostic probe to detect BC using PET/MRI technique.
Reference Key
hajiramezanali2019garadiolabeledinternational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hajiramezanali, Maliheh;Atyabi, Fatemeh;Mosayebnia, Mona;Akhlaghi, Mehdi;Geramifar, Parham;Jalilian, Amir Reza;Mazidi, Seyed Mohammad;Yousefnia, Hassan;Shahhosseini, Soraya;Beiki, Davood;
Journal international journal of nanomedicine
Year 2019
DOI
10.2147/IJN.S195223
URL
Keywords Keywords not found

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