Water-soluble Glucosamine-coated AIE-Active Organic Nanoparticles: Design, Synthesis and Assembly for Specific Detection of Heparin Based on Carbohydrate-carbohydrate Interactions.

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ID: 39275
2019
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Abstract
Two water-soluble carbohydrate-coated AIE-activate fluorescent organic nanoparticles TPE3G and TPE4G were designed and synthesized for the detection of heparin. Different from the reported strategy, we not only utilized the general detection mechanism electrostatic interactions, but also introduced the concept of carbohydrate-carbohydrate interactions (CCIs) to enrich the detection mechanism of heparin. TPE3G can be served as an efficient "turn-on" probe with higher selectivity towards heparin than TPE4G. TEM studies revealed that the micro-aggregated TPE3G was encapsulated with heparin chain to form a complex self-assemblied composites and emit strong fluorescence. It is believed that the results illustrated in this study provide a novel strategy based on CCls to design water-soluble and more efficient bio-probes for various biological and clinical applications.
Reference Key
xing2019watersolublechemistry Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Xing, Guo-Wen;Ji, Yan-Ming;Liu, Guang-Jian;Li, Cui-Yun;Liu, Yi-Chen;Hou, Min;
Journal Chemistry, an Asian journal
Year 2019
DOI
10.1002/asia.201901153
URL
Keywords Keywords not found

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