Inhaled GM-CSF in neonatal mice provides durable protection against bacterial pneumonia.

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ID: 38598
2019
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Abstract
Pneumonia poses profound health threats to preterm infants. Alveolar macrophages (AMs) eliminate inhaled pathogens while maintaining surfactant homeostasis. As AM development only occurs perinatally, therapies that accelerate AM maturation in preterms may improve outcomes. We tested therapeutic rescue of AM development in mice lacking the actin-bundling protein L-plastin (LPL), which exhibit impaired AM development and increased susceptibility to pneumococcal lung infection. Airway administration of recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) to LPL neonates augmented AM production. Airway administration distinguishes the delivery route from prior human infant trials. Adult LPL animals that received neonatal GM-CSF were protected from experimental pneumococcal challenge. No detrimental effects on surfactant metabolism or alveolarization were observed. Airway recombinant GM-CSF administration thus shows therapeutic promise to accelerate neonatal pulmonary immunity, protecting against bacterial pneumonia.
Reference Key
todd2019inhaledscience Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Todd, Elizabeth M;Ramani, Rashmi;Szasz, Taylor P;Morley, S Celeste;
Journal Science advances
Year 2019
DOI
10.1126/sciadv.aax3387
URL
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