TRANSCRIPTIONAL FA CTORS FOXP3, GATA-3, PAX-5 AND THEIR COOPERAT IVE INTERACTIONS IN BRONCHIAL ASTHMA

Abstract. The review article summarizes current information about transcriptional factors Fохр3, GATA- 3, РАХ-5 and their cooperative interactions. Predomination of one of these factors leads to production of corresponding cytokines and appropriate changes in T and B cell functions, thus causing development of different inflammatory events and typical symptoms. Focusing the discussion on Foxp3, GATA-3 and PAX- 5 is essential for understanding pathogenesis of inflammatory lung diseases, in particular, bronchial asthma. The data obtained will be helpful in development of novel therapeutic strategies. Mechanisms of cooperative interactions of Fохр3, GATA-3 and РАХ-5, generally, remain poorly understood. In this article, we present modern, sometimes, controversial views on this issue. In particular, we are discussing regulation of Foxp3 expression, molecular interactions affecting production of PAX-5 factor, as well as addressing possible indirect interactions between these transcription factors via implementing GATA-3 and STAT6 functions.