New Butenolides and Cyclopentenones from Saline Soil-Derived Fungus .

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ID: 3805
2019
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Abstract
Three new -hydroxyl butenolides (-), a pair of new enantiomeric spiro-butenolides ( and ), a pair of enantiomeric cyclopentenones ( new and new natural), and six known compounds (-), were isolated from . Their structures were established by spectroscopic data and electronic circular dichroism (ECD) spectra. Two pairs of enantiomers [(+)/(-)- and (+)/(-)-] obtained from the reaction of with acetyl chloride (AcCl) confirmed that was a mixture of two pairs of enantiomers. In addition, the X-ray data confirmed that was also a racemate. The new metabolites (- were evaluated for their inhibitory activity against cancer and non-cancer cell lines. As a result, compound exhibited moderate cytotoxicity to HL60 and A549 with IC values of 6.5 and 8.9 µM, respectively, and weak potency to HL-7702 with IC values of 17.6 µM. Furthermore, compounds - were screened for their antimicrobial activity using the micro-broth dilution method. MIC values of 200 μg/mL were obtained for compounds and towards and , while compound exhibited a MIC of 50 μ/mL towards .
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ma2019newmolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ma, Li-Ying;Zhang, Huai-Bin;Kang, Hui-Hui;Zhong, Mei-Jia;Liu, De-Sheng;Ren, Hong;Liu, Wei-Zhong;
Journal molecules
Year 2019
DOI
E2642
URL
Keywords Keywords not found

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