Cell Type Influences Local Delivery of Biomolecules from a Bioinspired Apatite Drug Delivery System

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ID: 37243
2018
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Ranked #305 of 812 articles by views in Materials (Basel, Switzerland)

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Abstract
Recently, the benefit of step-wise sequential delivery of fibroblast growth factor-2 (FGF-2) and bone morphogenetic protein-2 from a bioinspired apatite drug delivery system on mouse calvarial bone repair was demonstrated. The thicknesses of the nanostructured poly-l-Lysine/poly-l-Glutamic acid polyelectrolyte multilayer (PEM) and the bone-like apatite barrier layer that make up the delivery system, were varied. The effects of the structural variations of the coating on the kinetics of cell access to a cytotoxic factor delivered by the layered structure were evaluated. FGF-2 was adsorbed into the outer PEM, and cytotoxic antimycin-A (AntiA) was adsorbed to the substrate below the barrier layer to detect the timing of the cell access. While MC3T3-E1 osteoprogenitor cells accessed AntiA after three days, the RAW 264.7 macrophage access occurred within 4 h, unless the PEM layer was removed, in which case the results were reversed. Pits were created in the coating by the RAW 264.7 macrophages and initiated delivery, while the osteoprogenitor cell access to drugs occurred through a solution-mediated coating dissolution, at junctions between the islands of crystals. Macrophage-mediated degradation is therefore a mechanism that controls drug release from coatings containing bioinspired apatite.
Reference Key
alhamdi2018cellmaterials Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Alhamdi, Jumana;Jacobs, Emily;Gronowicz, Gloria;Benkirane-Jessel, Nadia;Hurley, Marja;Kuhn, Liisa;
Journal Materials (Basel, Switzerland)
Year 2018
DOI
DOI not found
URL
http://www.mdpi.com/1996-1944/11/9/1703
Keywords Keywords not found

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