TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala.

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ID: 36405
2019
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Abstract
TMEM16B (ANO2) is the Ca-activated chloride channel expressed in multiple brain regions, including the amygdala. Here we report that knockout mice exhibit impaired anxiety-related behaviors and context-independent fear memory, thus implicating TMEM16B in anxiety modulation. We found that TMEM16B is expressed in somatostatin-positive (SOM) GABAergic neurons of the central lateral amygdala (CeL), and its activity modulates action potential duration and inhibitory postsynaptic current (IPSC). We further provide evidence for TMEM16B actions not only in the soma but also in the presynaptic nerve terminals of GABAergic neurons. Our study reveals an intriguing role for TMEM16B in context-independent but not context-dependent fear memory, and supports the notion that dysfunction of the amygdala contributes to anxiety-related behaviors.
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li2019tmem16belife Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Li, Ke-Xin;He, Mu;Ye, Wenlei;Simms, Jeffrey;Gill, Michael;Xiang, Xuaner;Jan, Yuh Nung;Jan, Lily Yeh;
Journal eLife
Year 2019
DOI
10.7554/eLife.47106
URL
Keywords Keywords not found

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