Tissue damage in the heart after cardiac arrest induced by asphyxia and hemorrhage in newborn pigs.

Clicks: 344
ID: 3569
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Star

Ranked #22 of 80 articles by views in Pediatric research

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Asphyxia of newborns is a severe and frequent challenge of the peri- and postnatal period.Forty-four neonatal piglets underwent asphyxia and hemorrhage (AH), followed by resuscitation with blood or crystalloid transfusion. In this study, 15 piglets (blood n = 9, NaCl n = 6, mean age 31 h) were randomly chosen. Four hours after return of spontaneous circulation, heart tissue and blood were collected. Analyses of heart fatty acid binding protein (HFABP), cardiac troponin I (TnI) levels, and activation of the complement system were performed. Histological staining for connexin 43 (Cx43) and complement C5a receptor 1 (C5aR1) was performed.Following AH, systemic elevation of cardiac TnI and HFABP revealed cardiac damage in both groups. Systemic activation of the complement system and the appearance of extracellular histones in plasma of the blood transfusion group were observed. The Cx43 was translocated from the intercalated discs to the cytosol after AH. Cardiac glycogen concentration was reduced in both groups. A significant reduction of C5aR1 in the left ventricle and a significant elevation of the heart injury score were investigated after blood transfusion.AH leads to alteration of the heart, particularly in Cx43 and glycogen reserves, as well as local inflammation.
Reference Key
weber2019tissuepediatric Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Weber, Birte;Robin Mendler, Marc;Lackner, Ina;Pressmar, Jochen;Haffner-Luntzer, Melanie;Höfler, Severin;Karl Braun, Christian;Hummler, Helmut;Schwarz, Stephan;Kalbitz, Miriam;
Journal Pediatric research
Year 2019
DOI
10.1038/s41390-019-0505-6
URL
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.