Design, Synthesis and Anti-Platelet Aggregation Activity Study of Ginkgolide-1,2,3-triazole Derivatives

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ID: 35525
2019
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Abstract
Ginkgolides are the major active component of Ginkgo biloba for inhibition of platelet activating factor receptor. An azide-alkyne Huisgen cycloaddition reaction was used to introduce a triazole nucleus into the target ginkgolide molecules. A series of ginkgolide-1,2,3-triazole conjugates with varied functional groups including benzyl, phenyl and heterocycle moieties was thus synthesized. Many of the designed derivatives showed potent antiplatelet aggregation activities with IC50 values of 5~21 nM.
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cui2019designmolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Cui, Jian;Hu, Le’An;Shi, Wei;Cui, Guozhen;Zhang, Xumu;Zhang, Qing-Wen;
Journal molecules
Year 2019
DOI
DOI not found
URL
https://www.mdpi.com/1420-3049/24/11/2156
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