Design, synthesis, and molecular docking study of new piperazine derivative as potential antimicrobial agents.

Clicks: 516
ID: 34233
2019
Article Quality & Performance Metrics
Overall Quality Improving Quality
79.7 /100
Combines engagement data with AI-assessed academic quality
AI Quality Assessment 🥈 High Quality
81.6 /100
Academic Rigor 88.0%
Novelty 78.0%
Clarity 85.0%
Key Strengths
  • Comprehensive characterization of synthesized compounds
  • Evaluation against a panel of bacterial and fungal strains
  • Molecular docking studies provide insights into potential mechanisms
Areas for Improvement
  • Limited discussion of the structure-activity relationship
  • The in vitro results need to be validated by in vivo studies
  • The novelty of the piperazine derivatives could be further emphasized
AI Recommendations

Expand the discussion on the structure-activity relationship to provide a deeper understanding of the observed antimicrobial activity. Consider including a section on the limitations of the study and future research directions. Further elaborate on the novelty of the synthesized compounds compared to existing antimicrobial agents.

Enhanced v2.0 Analysis NISO/DORA Compliant
NISO/DORA Compliant
High Impact
📊 Established
Topic Trend
2025 Relevance
Relevance
0%
Importance
0%
Authorship
Unknown
Authors
0
Diversity
0%
Research Integrity
COPE Standards
Integrity
0%
Innovation
0%
Interdisciplinary Value
🔀 Cross-disciplinary
60%
Practical Impact Potential
Real-world Applications
75%
Enhanced Evaluation v2.0: Following NISO RP-25-2016, DORA 2025, and COPE assessment standards with 13 quality dimensions.
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Ranked #12 of 133 articles by views in Bioorganic chemistry

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Abstract
Herein, we describe the successful design and synthesis of seventeen new 1,4-diazinanes, compounds commonly known as piperazines. This group of piperazine derivatives (3a-q) were fully characterized by H NMR, C NMR, FT-IR, and LCMS spectral techniques. The molecular structure of piperazine derivative (3h) was further established by single crystal X-ray diffraction analysis. All reported compounds were evaluated for their antibacterial and antifungal potential against five bacterial (Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa) and two fungal strains (Candida albicans and Cryptococcus neoformans). The complete bacterial screening results are provided. As documented, piperazine derivative 3e performed the best against these bacteria. Additionally, data obtained during molecular docking studies are very encouraging with respect to potential utilization of these compounds to help overcome microbe resistance to pharmaceutical drugs, as explicitly noted in this manuscript.
Reference Key
patil2019designbioorganic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Patil, Mahadev;Noonikara Poyil, Anurag;Joshi, Shrinivas D;Patil, Shivaputra A;Patil, Siddappa A;Bugarin, Alejandro;
Journal Bioorganic chemistry
Year 2019
DOI
S0045-2068(19)31140-X
URL
Keywords Keywords not found

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