Genetically Predicted Childhood Adiposity and Adult Arterial Plaque Burden: New Insights from Genetic Epidemiology

Clicks: 3
ID: 339137
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #82 of 83 articles by views in European Heart Journal Open

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Aims The causal relationship between childhood adiposity and adult arterial plaque burden remains to be established. Methods and results Two-sample Mendelian randomization (MR) was used to examine the associations of genetically predicted childhood body mass index (BMI) with coronary plaque burden (PB), coronary artery calcification (CAC), and carotid plaque (CP). Multivariable MR and mediation analyses were further performed to explore whether adult BMI, lipid traits, hypertension, or type 2 diabetes (T2D) mediated these associations. A genetically predicted 1-standard deviation increase in childhood BMI was associated with higher coronary PB (β = 0.326; 95% CI, 0.142–0.511) and CAC (β = 0.114; 95% CI, 0.032–0.196), but not CP (β = −0.095; 95% CI, −0.264 to 0.073). Multivariable analyses showed that these associations remained significant after adjustment for low-density lipoprotein cholesterol and T2D, but were attenuated after adjustment for adult BMI, high-density lipoprotein cholesterol, triglycerides (TG), or hypertension—each identified as a significant mediator, with TG accounting for the largest mediated proportion (15.6% for PB; 16.2% for CAC). Conclusions This MR study supports a causal role of childhood adiposity in adult coronary PB and CAC, mediated substantially through adult adiposity, dyslipidemia, and hypertension.
Reference Key
openalex_W7225389145 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Haozhang Huang, Ming Chen, Xiaozhao Lu, Huangtao Ruan, Haowen Li, Jin Liu, Shiqun Chen, Yong Liu
Are you one of these authors? Claim your profile
Journal European Heart Journal Open
Year 2026
DOI
10.1093/ehjopen/oeag191
URL
https://doi.org/10.1093/ehjopen/oeag191
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.