Assessing mediation of sexual orientation disparities in miscarriage by age at pregnancy, gravidity, and use of medically assisted reproduction in four national cohorts

Clicks: 2
ID: 338804
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #379 of 383 articles by views in american journal of epidemiology

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 383 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Recent research has documented a higher miscarriage risk among sexual minority individuals than heterosexual individuals. These disparities may be partly mediated by age at pregnancy, gravidity, and use of medically assisted reproduction (MAR). We used data from four cohorts (Nurses' Health Study 2 and 3, Growing Up Today Study, and National Longitudinal Study of Adolescent to Adult Health) to estimate randomized interventional analogues of mediational direct and indirect effects of sexual orientation on miscarriage (pure natural direct effects [rPNDE], total natural indirect effects [rTNIE], and proportions mediated [rPM]). We found that pregnancies to sexual minority individuals were more likely to end in a miscarriage than those to heterosexual individuals. We found weak mediation of this effect by age (rPNDE: 1.23, 95% confidence interval [CI]: 1.15-1.32; rTNIE: 1.02, 95% CI: 1.01-1.03; rPM: 12%, 95% CI: 5%-19%), but not gravidity (rPM: 2%, 95% CI: -1%-6%) and MAR use (rPM: -1%, 95% CI: -4%-3%). While these factors impact miscarriage risk, our findings suggest that sexual orientation disparities in miscarriage are only minimally explained by age, and not explained by gravidity and use of MAR, contributing to the understanding of the role of pregnancy-related factors vs. structural factors in sexual orientation disparities in miscarriage.
Reference Key
openalex_W7225295531 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Payal Chakraborty, Colleen A. Reynolds, Isa Berzansky, Jorge E. Chavarro, Juno Obedin‐Maliver, Bethany G. Everett, Sebastien Haneuse, Brittany M. Charlton
Are you one of these authors? Claim your profile
Journal american journal of epidemiology
Year 2026
DOI
10.1093/aje/kwag290
URL
https://doi.org/10.1093/aje/kwag290
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.