Higher Diagnostic Yield of Sputum Versus Oropharyngeal Swabs for Viral Pathogens in Hospitalized Non-COVID-19 Community-acquired Pneumonia

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ID: 338590
2026
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Abstract
Abstract Rapid and accurate pathogen detection is crucial for managing community-acquired pneumonia (CAP) and guiding infection control. Among 229 hospitalized adults with paired specimens, multiplex PCR detected respiratory viruses in 65% of sputum samples compared with 39% of oropharyngeal swabs, indicating higher diagnostic yield with sputum in moderate-to-severe CAP.
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Authors Pei Min Thong, Dorothy Hui Lin Ng, Sharlene Ho, Say Tat Ooi, Faheem Khan, Paul Anantharajah Tambyah, Tsin Wen Yeo, Barnaby Edward Young, I3D RESPIRO study group, Puah Ser Hon, Glenn Yong Khai Wern, Sapna Pradip Sadarangani, Samuel Wang Sherng Young, Loo Yan Tong, Faith Evangeline Ong Jie Qi, Travis Chia Ren Teen, Leong Wei Yee, Yeo He Ping, Harini S Shunmuga Velu, Diong Shiau Hui, Jonathan Jordan Lim Cailu, Mohammed Ridzwan Bin Abdullah, Matthew Cove, Nicholas Ngiam Jinghao, Gabriel Yan Zherong, Mo Yin, Dinah binte Aziz, Abdurrahmaan Al-Mubaarak Bin Eliase, Nur Qasrina Binte Iskandar Lim, Smeetha Nair, Ryanna Koh Wei Ren, Sandy Ling Qian Hui, Choi Ji Eun, Kiran Sidhu, Jenny Low Guek Hong, Shirin Kalimuddin, Yvonne Chan Fu Zi, Tan Yi Hern, Sewa Duu Wen, Esther Tan Qiao Li, Ken Lee Cheah Hooi, Michelle Koh Siew Hui, Candice Chan Yuen Yue, Danny Tng Jian Hang, Vera Goh Jin Ling, Sam Hui Zhen, Faline Yang Yu Chen, Leona Quek Yan Peng, Weng Chenxin, Felicia Lea Chu Yan, Charlene Cheong Suk Teng, Sandy Sim Xue Qi, Nur Azra Aqilah Mohamed Badruzamam, Kearney Tan Jun Yao, Filzah Insyirah Binte Zainal Abidin, Michellore Aguilar Dannug, Au Zi Ning, Amirah Anuar, Erinn Choong Jade Yi, Tee Kai Sin, 路 刘, Sun Weixue, Sarah Teo Yu Wei, Nyein Chan Maung, Rachel Choo Zhi Ting, Tan Ze Ying, Shoban Krishna Kumar, Chong Keenan, Dhanvijay Shekhar, Manasa Sachin Kumar, Ray Lin Junhao, Alicia Ang Xin Yu, Andrew Li Yunkai, Doris Zhang Chunfei, Shawn Sushilan Vasoo, Conrad Chan En Zuo, Siti Nurdiana Binte Abas, Raika Francesca Morales, Nurhidayah Binte Mohamed Yazid, Hon Pei Yun, Ong Jin Ting, Raymond Lin Tzer Pin, Cui Lin, Ma Weiyao, Chen Bei Bei, Claudia Thng, Chung Miao Ling, Ng Wei Zhen, Tay En Xin, Timothy Wong, Andrew Teo Chin Chye
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Journal Open forum infectious diseases
Year 2026
DOI
10.1093/ofid/ofag722
URL
https://doi.org/10.1093/ofid/ofag722
Keywords Keywords not found

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