Large Peritoneal Macrophages influence CD8+ T cell activation and parasite control during acute Trypanosoma cruzi infection

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ID: 338496
2026
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Abstract
Abstract Resident peritoneal macrophages consist of two subpopulations with distinct origin, sizes and phenotype named Large Peritoneal Macrophages (LPMs) and Small Peritoneal Macrophages (SPMs). While LPMs are long-live cells that origin in embryonic yolk sac and can self-replenish after mild loss, SPMs are short-live cells that derive from blood monocytes and are in continuous replenishment. Under homeostasis, LPMs constitute more than 70% of total CD11b+ cells, but during infection or inflammation drastically dampen. As LPMs have been reported to be essential for CD8+ T cell priming and replication control in parasite infections, we aimed to study their role in the context of Chagas’ disease. We observed a reduction in LPMs during acute phase of T. cruzi infection in BALB/c mice that did not restore in chronic phase. Instead, this subset was replaced by a population with intermediate expression of F4/80, previously described as ‘inflammatory macrophages’, but with a mixed phenotype activation in this case. Besides, this F4/80int population could also be associated with truncated maturation of monocytes to resident macrophages. In this work, LPMs showed higher CD80+ and lower PD-L1+ cells frequencies and produced more IL-12 and TNF than SPMs. This profile may favor CD8+ T-cell activation, reflected by increased CD69 expression and Perforin/Granzyme B production. Replenishment of LPMs by adoptive transfer of PEMs was associated with reduced parasitemia and enhanced splenic CD8+ T-cell activation. Thus, LPMs may contribute to CD8+ T-cell responses and parasite control during acute T. cruzi infection.
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Authors Ruth Eliana Baigorrí, María Estefania Viano, Florencia Hellriegel, Camila Fontanari, Gastón Bergero, Yanina L Mazzocco, Matias Ezequiel Vázquez Vignale, María Belén Brugo, Claudia Cristina Motrán, María Pilar Aoki, María Cecilia Rodriguez‐Galán, Cinthia Carolina Stempin, Fabio M. Cerbán
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Journal journal of leukocyte biology
Year 2026
DOI
10.1093/jleuko/qiag139
URL
https://doi.org/10.1093/jleuko/qiag139
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