Senescence “telephone” following ACL tears: a new role for macrophages

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ID: 338325
2026
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Abstract
Muscle atrophy following orthopaedic injury is a nearly ubiquitous hindrance to functional recovery. This perspective discusses new research that suggests that senescent macrophages, which infiltrate the quadriceps muscle acutely after ACL injury in mice, may contribute to atrophy and fibrosis by propagating senescence. The intriguing possibility that these senescent macrophages are shared across musculoskeletal tissues combined with evidence that clearance of senescent cells by senolytics improves both skeletal muscle and cartilage, points to senescent macrophages as a promising early therapeutic target worthy of further exploration.
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openalex_W7225153556 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gretchen A. Meyer
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Journal Food & function
Year 2026
DOI
10.1152/function.90006.2026
URL
https://doi.org/10.1152/function.90006.2026
Keywords Keywords not found

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