Transplantation and the HIV Latent Viral Reservoir

Clicks: 12
ID: 337643
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #491 of 503 articles by views in The Journal of infectious diseases

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 503 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Despite antiretroviral therapy, the latent viral reservoir (LVR) remains the primary barrier to HIV cure. Both hematopoietic and solid organ transplantation (SOT) have provided optimism for cure and significant insights into LVR composition and maintenance. There have been thirteen reported cases of acquired cure, all in individuals receiving allogeneic hematopoietic stem cell transplants (allo-HSCT). While infeasible for most, these cases have provided important lessons about the LVR. Impacts of SOT on the LVR have also been investigated. In kidney transplantation where recipients were T-cell depleted, the LVR initially decreased before rebounding, and eventually surpassed the LVR of recipients without T-cell depletion. Despite transplanting a large lymphoid organ, studies have found no impact of HIV+ liver transplants on LVR size in recipients. Given that SOTs are more accessible globally than allo-HSCTs, lessons learned about the LVR from these studies can inform potential cure avenues that may be more feasible and attainable.
Reference Key
openalex_W7224092508 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors J Natalie Howard, Melissa Laird Smith, Ashwin Balagopal, Christine M. Durand, Andrew D. Redd, Aaron A.R. Tobian
Are you one of these authors? Claim your profile
Journal The Journal of infectious diseases
Year 2026
DOI
10.1093/infdis/jiag526
URL
https://doi.org/10.1093/infdis/jiag526
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.