Human infections caused by filamentous basidiomycetes: A global systematic review

Clicks: 11
ID: 337613
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #185 of 187 articles by views in medical mycology

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 187 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Filamentous basidiomycetes are increasingly recognized as causes of diverse human disease, yet knowledge of their clinical spectrum, diagnosis, treatment, antifungal susceptibility, and outcomes remains fragmented. We systematically reviewed published clinically significant human infections caused by filamentous basidiomycetes. Clinical, microbiological, radiological, treatment, susceptibility, and outcome data were extracted, cases from India were compared with those from the rest of the world (RoW), and logistic regression identified independent mortality predictors. Antifungal susceptibility data were summarized descriptively. We included 253 cases from 112 studies, comprising 56 from India and 197 from RoW. Respiratory or sinonasal disease without demonstrated tissue invasion predominated, although invasive and localized/non-invasive disease also occurred. Among patients with known immune status, 61.7% were immunocompetent, significantly more frequently in India. Schizophyllum commune (38.3%), Bjerkandera adusta (29.2%), and Hormographiella aspergillata (9.5%) predominated. Molecular sequencing was used for species-level identification in 62.5% of cases. Outcomes were available for 238 patients; 33 died (13.9%). Immunocompromised status (adjusted odds ratio [aOR], 7.12; 95% CI, 1.44–35.19) and histologic invasion (aOR, 3.19; 95% CI, 1.10–9.28) independently predicted mortality, whereas surgery was associated with lower observed mortality (aOR, 0.07; 95% CI, 0.01–0.66), although causality cannot be inferred. Amphotericin B and mold-active triazoles, particularly voriconazole, posaconazole, and isavuconazole, showed the most favorable in vitro activity, whereas fluconazole, 5-flucytosine, and echinocandins showed limited activity. Filamentous basidiomycetes cause a broad spectrum of disease in immunocompetent and immunocompromised hosts. Molecular identification is essential for accurate diagnosis, while immune status and tissue invasion are important independent determinants of adverse clinical outcomes.
Reference Key
openalex_W7224110809 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sneha Vinayan, Nagarathna Siddaiah, Arghadip Samaddar
Are you one of these authors? Claim your profile
Journal medical mycology
Year 2026
DOI
10.1093/mmy/myag115
URL
https://doi.org/10.1093/mmy/myag115
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.