Beyond a covariate: sex as a mechanistic determinant of Immunometabolism

Clicks: 8
ID: 337602
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #41 of 46 articles by views in Clinical & Experimental Immunology

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
In the past two decades, two major conceptual advances that have shaped the modern immunological field are the establishment of immunometabolism as a discipline and the growing understanding of how immune systems can drastically differ based on sex. Considering the well-known wide-ranging impact of sex on metabolic processes, these innovations would potentially be expected to be intricately linked. However, the majority of immunometabolism studies do not consider sex, or treat sex as a covariate that should be statistically adjusted for. Therefore, most studies interrogating how metabolic processes impact immune cell function may conceal how these processes are fundamentally different in males and females, and how they may shift in response to changing sex hormone levels across the lifespan. In this perspective, we argue that sex should be treated as a fundamental mechanistic input in immunometabolism, rather than solely as a statistical confounder or covariate, with direct consequences for how existing and new data are interpreted, and for how new therapies for immunometabolic health conditions are developed.
Reference Key
openalex_W7224095912 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Elizabeth C. Rosser, Diana Matei
Are you one of these authors? Claim your profile
Journal Clinical & Experimental Immunology
Year 2026
DOI
10.1093/cei/uxag065
URL
https://doi.org/10.1093/cei/uxag065
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.