T cell metabolic ageing as a factor for therapeutic research

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ID: 337445
2026
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Abstract
Ageing is an important determinant of immune function across the lifespan, yet it remains underappreciated in the design and interpretation of much basic T cell research. As the immune system ages, T cell responses become less diverse, less efficient, and less adaptable, with consequences for infection control, vaccine responsiveness, cancer immunosurveillance, and the performance of T cell-based immunotherapies. This issue is particularly acute because many fundamental studies still rely on T cells from, mostly, healthy young donors. These controls are indispensable, but the field has built much of its pre-clinical logic on immune systems that are younger, fitter, and biologically distinct from the patients for whom T cell therapies are intended. We argue that this mismatch between experimental systems and clinical reality could be overcome by considering age as a routine variable from the start.
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Authors Ellen King, Bahar Zinali Sohanaki, Anna Schurich
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Journal Clinical & Experimental Immunology
Year 2026
DOI
10.1093/cei/uxag066
URL
https://academic.oup.com/cei/advance-article-pdf/doi/10.1093/cei/uxag066/72530898/uxag066.pdf
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