Cardiovascular Disease Risk in Individuals with Complex and Disabling Health Conditions: A Systematic Review and Meta-analysis

Clicks: 9
ID: 334063
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #73 of 80 articles by views in European Heart Journal Open

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Aim To quantify cardiovascular disease (CVD) risk among individuals with multiple sclerosis (MS), spinal cord injury (SCI), traumatic brain injury (TBI), cerebral palsy (CP), poliomyelitis, or spina bifida, and examine the roles of traditional risk factors and condition-specific characteristics. Methods We systematically searched Embase, MEDLINE, and Web of Science from inception to March 2025. Two reviewers independently screened studies, extracted data, and assessed risk of bias. Random-effects meta-analyses were conducted, and heterogeneity, publication bias, and study quality were evaluated. Sex was considered according to SAGER guidelines. Results Thirty-eight studies involving over 1.6 million individuals were included. Individuals with disabling conditions had higher CVD risk estimates than the general population (IRR = 1.80; HR = 1.83; OR = 2.21). Substantial between-study heterogeneity was observed. MS and SCI were associated with increased risks of stroke, myocardial infarction, and heart failure, while TBI was particularly associated with stroke. Traditional risk factors, including age, sex, diabetes, dyslipidemia, and hypertension, and condition-specific characteristics, including injury severity and recurrence in TBI, injury level in SCI, disease severity in MS, and non-traumatic fractures in CP, were associated with CVD risk or variation in risk estimates. Evidence for some conditions was limited. Conclusions Individuals with disabling conditions had higher CVD risk estimates than the general population, although substantial heterogeneity warrants cautious interpretation. Further research is needed to determine whether tailored cardiovascular risk assessment and preventive strategies improve outcomes.
Reference Key
openalex_W7223649553 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yan Xu, E L E N A Koelbener, Catherine Ruth Jutzeler, Inge Eriks Hoogland, Beatrice Minder, Angèle Gayet‐Ageron, Sungchul Huh, Julia Patrick Engkasan, Sintip Pattanakuhar, Carla Sabariego, Marija Glišić
Are you one of these authors? Claim your profile
Journal European Heart Journal Open
Year 2026
DOI
10.1093/ehjopen/oeag182
URL
https://doi.org/10.1093/ehjopen/oeag182
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.