Minimally invasive lobectomy following pathologic complete response to neoadjuvant Lorlatinib in ALK-positive squamous cell carcinoma

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ID: 333648
2026
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Ranked #128 of 147 articles by views in Interdisciplinary CardioVascular and Thoracic Surgery

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Abstract
Abstract ALK rearrangements are uncommon in lung squamous cell carcinoma, and neoadjuvant ALK inhibition remains investigational. We report a 52-year-old never-smoking female with stage IIIB ALK-positive squamous cell carcinoma treated with neoadjuvant lorlatinib for 12 weeks. Serial imaging demonstrated a 61% reduction in tumor size with nodal regression. The patient subsequently underwent a uniportal video-assisted thoracoscopic (uVATS) lobectomy, and final pathology revealed a complete pathological response (pCR) of the primary tumor. This case highlights the feasibility and safety of minimally invasive anatomical lung resection following neoadjuvant lorlatinib despite treatment-related hilar fibrosis and vascular–bronchial adhesions.
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Authors Alexandra Molkova, Ruifeng Li, Shuben Li
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Journal Interdisciplinary CardioVascular and Thoracic Surgery
Year 2026
DOI
10.1093/icvts/ivag280
URL
https://academic.oup.com/icvts/advance-article-pdf/doi/10.1093/icvts/ivag280/72385320/ivag280.pdf
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