EBV-infected cell lineage by EBER double-staining as a diagnostic and prognostic clue in pediatric EBV-related lymphoproliferative disorders: a Japanese central pathology cohort study

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ID: 333410
2026
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Abstract
Abstract We retrospectively analyzed 36 children with Epstein-Barr virus-related lymphoproliferative disorder (EBV-LPD) from the Japan Children's Cancer Group (2006-2021), focusing on diagnostically challenging lesions not definitively classified as lymphoma. Using EBER in situ hybridization double-staining, we confirmed EBV infection primarily in T/NK cells (EBV-T/NK-LPD, n = 17) or B cells (EBV-B-LPD, n = 16). Lymphoid follicle architecture was effaced in EBV-T/NK-LPD (89%) and EBV-B-LPD (54%). 5-year overall survival was lower for EBV-T/NK-LPD (59%) than EBV-B-LPD (93%). Determining the EBV-infected cell lineage enables clinically relevant classification and risk stratification, and can be applied to archival specimens, including lesions initially interpreted as reactive.
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Authors Rintaro Ono, Kenichi Sakamoto, Kunihiko Moriya, Akihiro Hoshino, Kentaro Ohki, Nobutaka Kiyokawa, Hideto Iwafuchi, Takako Yoshioka, Hirokazu Kanegane, Ken‐Ichi Imadome, Masahiro Sekimizu, Yoko Shioda, Atsuko Nakazawa
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Journal The Journal of infectious diseases
Year 2026
DOI
10.1093/infdis/jiag523
URL
https://doi.org/10.1093/infdis/jiag523
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