Pre-Clinical Assessment of Early Interaction Between Absorbable P4HB Scaffolds and Silicone Breast Implants

Clicks: 6
ID: 333306
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #119 of 125 articles by views in Aesthetic Surgery Journal Open Forum

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 125 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Background Absorbable scaffolds such as poly-4-hydroxybutyrate (P4HB) are increasingly used in aesthetic breast surgery to support implants. However, the nature and timing of scaffold–implant interactions during early healing remain uncharacterized. Objectives Evaluate whether contact between P4HB Scaffolds and silicone implants can cause mechanical weaking of either device or wear-related particulate generation. Methods Two independent studies were performed. An animal study assessed early P4HB Scaffold-tissue integration. Characteristics and histology of scaffold explants were compared to native capsules after 4 weeks in a porcine silicone implant model. A separate benchtop study evaluated scaffold and implant mechanical integrity and particulate generation after interactive cyclic loading for 12 weeks, exceeding the in vivo integration period, to conservatively evaluate interaction. Mechanical testing was performed of implants and scaffolds after interaction and compared to non-tested devices. Particulate analysis was performed on fluid collected from the bench apparatus. Results Scaffold-tissue capsules show surface characteristics similar to native tissue capsules, indicating complete integration at 4-weeks. After 12-week benchtop loading, mechanical properties of scaffolds and implants were comparable to controls and met standard specifications for new devices. Particulates were below detection limits. Conclusions This preclinical study evaluated early scaffold–implant interaction during the period of maximal direct polymer contact and assessed mechanical interactions under worst-case simulated conditions. By 4 weeks in animals, tissue integration limits direct polymer–implant contact. After 12 weeks on the bench, no compromise of implant or scaffold mechanical integrity or detectable particulates were observed under the tested conditions. These findings provide preliminary data and do not address long-term effects.
Reference Key
openalex_W7223151579 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Cassandra Vanhamme, Darcy H. Gagne, Cameron Bloomquist, Ashley McLaughlin, Diana Catalina Ardila, Tyler Stahl, Catherine C. Steele, Amit Badhwar, Sakib F. Elahi
Are you one of these authors? Claim your profile
Journal Aesthetic Surgery Journal Open Forum
Year 2026
DOI
10.1093/asjof/ojag205
URL
https://doi.org/10.1093/asjof/ojag205
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.