Endoscopic and histologic healing distribution and persistent rectosigmoiditis in moderate-to-severe ulcerative colitis

Clicks: 13
ID: 333258
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #94 of 101 articles by views in inflammatory bowel diseases

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Background Mucosal healing in ulcerative colitis (UC) is believed to follow a proximal-to-distal pattern. We evaluated colonic healing distribution in patients with moderate-to-severe UC receiving adalimumab. Methods Patients from the SERENE UC (Study of a Novel Approach to Induction and Maintenance Dosing with Adalimumab in Patients with Moderate to Severe Ulcerative Colitis) trial with full colonoscopies and segmental biopsies at screening, weeks 8, and 52 were included for endoscopic and histologic analyses if baseline Mayo endoscopic subscore (MES) or Robarts Histopathology Index (RHI) score, respectively, was >0 in the ascending, transverse, and/or descending colon. Data were analyzed using a mixed model for repeated measures to account for clustering of segments within a patient. Results Endoscopic and histologic analyses comprised 76 and 79 patients, respectively. Score reductions were significantly greater vs the rectum in the ascending (week 8: MES, mean −0.78 [95% confidence interval (CI), −1.03 to −0.52]; RHI, mean −4.70 [95% CI, −6.92 to −2.49]; week 52: MES, mean −0.63 [95% CI, −0.91 to −0.35]; RHI, mean −2.39 [95% CI, −4.64 to −0.15]), transverse (week 8: MES, mean −0.69 [95% CI, −0.94 to −0.43]; RHI, mean −3.57 [95% CI, −5.62 to −1.51]; week 52: MES, mean −0.64 [95% CI, −0.89 to −0.38]; RHI, mean −2.88 [95% CI, −4.99 to −0.77]), and descending colon (week 8: MES, mean −0.40 [95% CI, −0.67 to −0.13]; RHI, mean −2.55 [95% CI, −4.94 to −0.16]; week 52: MES, mean −0.52 [95% CI, −0.70 to −0.34]; RHI, mean −3.47 [95% CI, −5.37 to −1.56]). Endoscopic improvement/remission and histologic remission were significantly more likely in the ascending and transverse colon than the rectum. Conclusions Our findings demonstrate that endoscopic and histologic healing is more challenging in the rectum compared with proximal colonic segments.
Reference Key
openalex_W7223119106 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Christopher Ma, Jurij Hanžel, Rocío Sedaño, F. Stephen Laroux, Gregor Novak, Brian L. Bressler, Hannah Dong, Guangyong Zou, Stefanie C. McFarlane, Charles Noah Bernstein, Neeraj Narula, Rish K Pai, David F. Schaeffer, Remo Panaccione, Bruce E. Sands, Brian G. Feagan, Vipul Jairath
Are you one of these authors? Claim your profile
Journal inflammatory bowel diseases
Year 2026
DOI
10.1093/ibd/izag184
URL
https://doi.org/10.1093/ibd/izag184
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.