Comparison of 99mTc-Phytate and 99mTc-Antimony Trisulfide in sentinel lymph node detection: a lymphoscintigraphy study in breast cancer patients

Clicks: 6
ID: 333251
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #48 of 49 articles by views in Radiation protection dosimetry

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Sentinel lymph node biopsy is critical for breast cancer staging and management. While 99mTc-Phytate is the established standard radiotracer, 99mTc-Antimony Trisulfide has limited clinical application due to radiopharmaceutical supply constraints. This proof-of-concept study evaluates both radiotracers’ diagnostic effectiveness and validates 99mTc-Antimony Trisulfide as a viable alternative. This institutional study included 39 breast cancer patients undergoing sentinel lymph node biopsy. Patients received either 99mTc-Phytate (n = 28; 71.8%) or 99mTc-Antimony Trisulfide (n = 10; 25.6%) via periareolar (n = 24) or peritumoral (n = 15) injection. Sentinel lymph node identification and gamma probe concordance were analyzed. Mean patient age was 53.5 ± 9.5 years. Invasive ductal carcinoma predominated (87%). 99mTc-Phytate achieved 100% detection (28 of 28 patients), while 99mTc-Antimony Trisulfide achieved 90.9% (10 of 11 patients). Intraoperative gamma probe concordance was 100% in all successfully visualized cases (38 of 38). Both radiotracers effectively identify sentinel lymph nodes with high diagnostic accuracy. While 99mTc-Phytate remains the preferred first-line agent, 99mTc-Antimony Trisulfide represents a validated alternative, particularly valuable in resource-limited settings or during radiopharmaceutical supply disruptions.
Reference Key
openalex_W7223112375 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Saba Madani, Esmaeil Gharepapagh, Mehdi Salehi Barough, Noushin Benai Rezaieh, Majid Montazer, Morteza Azizi, Sahar Rezaei
Journal Radiation protection dosimetry
Year 2026
DOI
10.1093/rpd/ncag058
URL
https://doi.org/10.1093/rpd/ncag058
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.