Monocyte-Derived Dendritic Cell Activation Is Broadly Conserved Across Immune Phenotype-Specific Ovarian Tumor Lysate Pools, With Donor-Associated Variation in Response Magnitude

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ID: 332618
2026
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Abstract
Whether ex vivo monocyte-derived dendritic cell responses are shaped more by tumor immune context or donor-associated variation remains unclear. Monocyte-derived dendritic cells from nine healthy female donors were exposed for 8 h to three lysate pools generated from 27 high-grade serous ovarian tumors classified as immune-desert, immune-excluded, or immune-inflamed. Individual lysates showed phenotype-associated chemokine differences. The three pooled stimulation conditions elicited broadly conserved dendritic cell maturation responses and shared inflammatory transcriptional programs, with limited gene- and pathway-level differences. Permutational multivariate analysis attributed ≈58% of global transcriptional variance to donor identity (P = 0.001), whereas pooled lysate condition accounted for ≈4%, which was not significant (P = 0.756). Response magnitude varied continuously across donors and showed exploratory associations with baseline pathway activity in immature dendritic cells. Under the tested conditions, early monocyte-derived dendritic cell activation was broadly shared across the three lysate pools, while the transcriptional response magnitude was more strongly associated with donor identity.
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Authors Emilija Paberalė, Yasmine Hassan Mohamed Rezk, Jan Aleksander Kraśko, Karolina Suveizdė, Vita Pašukonienė, Agata Mlynska
Journal journal of leukocyte biology
Year 2026
DOI
10.1093/jleuko/qiag134
URL
https://doi.org/10.1093/jleuko/qiag134
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