Pancreatic steatosis is not associated with impaired insulin secretion among individuals with diabetes

Clicks: 15
ID: 332598
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #256 of 432 articles by views in the journal of clinical endocrinology & metabolism

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 432 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Aims We aimed to assess pancreatic and hepatic steatosis (PS/HS) association with residual insulin secretion and insulin resistance in individuals with diabetes. Methods Pancreatic/liver fat fractions (PFF/LFF) in magnetic resonance imaging (MRI) were used as a proxy for PS and HS in 170 participants. Insulin secretion was estimated by HOMA2-B, C-peptide response 6 minutes after an i.v. bolus of 0.5 mg glucagon (ΔC-Pe), and fasting proinsulin to C-peptide ratio (PI:C). Insulin resistance was estimated by HOMA2-IR, Adipo-IR and i.v. insulin (0.05 IU/kg) tolerance test. Results PFF did not correlate with measures of insulin secretion but it correlated with fasting indices of insulin resistance among women (HOMA2-IR, R = 0.26, p = 0.017; Adipo-IR, R = 0.29, p = 0.007). Both LFF and PFF correlated with BMI (R = 0.43 & R = 0.34, respectively, p < 0.001) but not with each other (R = 0.10, p = 0.215). Unlike PS, HS was associated with higher HOMA2-IR, Adipo-IR, HOMA2-B, PI:C and glucagon, after adjustment with confounders. Participants with PS without HS had lower fasting C-peptide, HOMA2-IR, HOMA2-B, Adipo-IR, glucagon and triglycerides (p < 0.05) compared to those having HS without PS. Cluster-based subgroups of diabetes did not differ in PF (p = 0.071). Conclusions Within this cohort, pancreatic fat was more strongly associated with adiposity than with the investigated measures of β-cell function or insulin resistance.
Reference Key
openalex_W7222664999 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors A LAITINEN, Katarina Johansson, Aki Juhani Käräjämäki, Annemari Käräjämäki, Jenny Häggblom, Liisa Hakaste, Samu H. Kurki, Kaj Lahti, Emma Ahlqvist, Jaakko Tuomilehto
Journal the journal of clinical endocrinology & metabolism
Year 2026
DOI
10.1210/clinem/dgag416
URL
https://academic.oup.com/jcem/advance-article-pdf/doi/10.1210/clinem/dgag416/72012831/dgag416.pdf
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.