Longitudinal olfactory and neuropsychological trajectories across the GBA1 spectrum

Clicks: 14
ID: 332592
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #159 of 194 articles by views in Brain communications

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 194 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Tracking non-motor symptoms and neuropsychological function is critical for assessing neurodegenerative progression. We characterized differences among individuals with Gaucher disease, GBA1 variant carriers, and GBA1-associated Parkinson disease to identify candidate markers of Parkinson disease-related change in Gaucher disease or GBA1 variant carriers. We analyzed data from 161 adults evaluated at the National Institutes of Health between 1983 and 2024, including 79 with Gaucher disease, 52 GBA1 variant carriers, and 30 with GBA1-associated Parkinson disease. Assessments included questionnaires for non-motor symptoms, depression, anxiety, fatigue, sleepiness, olfaction and intelligence quotient measures. Eighty-seven participants contributed longitudinal data from at least two visits. Linear mixed-effects models, adjusted for age, sex, and education, examined baseline differences and longitudinal trajectories. At baseline, the GBA1-associated Parkinson disease group showed lower olfactory performance (compared with both groups, P < 0.0001), greater daytime sleepiness (compared with GBA1 variant carriers, P = 0.003; compared with Gaucher disease, P = 0.0002), and higher non-motor symptom burden (compared with both groups, P < 0.0001). Only olfaction declined longitudinally, most steeply in GBA1-associated Parkinson disease (P < 0.0001; rate: 0.65 points per year, P = 0.032). In this longitudinal cohort, olfactory decline was the most robust marker differentiating GBA1-associated Parkinson disease from Gaucher disease and GBA1 variant carriers. Intelligence quotient and non-motor symptom measures did not demonstrate a comparable decline, reflecting their limited sensitivity to longitudinal change, and reinforcing the need for objective, biologically-based measures. Among participants without Parkinson disease at study onset, test scores remained stable over follow-up and phenoconversion was rare, underscoring the very low observed Parkinson disease penetrance among individuals with biallelic or heterozygous GBA1 variants.
Reference Key
openalex_W7222580049 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yonatan Serlin, Samantha Nishimura, Nishka Patel, Emory Ryan, Nahid Tayebi, Grisel J. Lopez, Ellen Sidransky
Are you one of these authors? Claim your profile
Journal Brain communications
Year 2026
DOI
10.1093/braincomms/fcag377
URL
https://doi.org/10.1093/braincomms/fcag377
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.