Evaluation of gut microbiota composition in elite controllers and antiretroviral-treated people with HIV after aspirin versus atorvastatin administration

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ID: 331980
2026
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Abstract
Abstract Gut dysbiosis is associated with chronic immune activation in people with HIV (PWH), but is not well-characterized in elite controllers (ECs) or PWH receiving aspirin or statins. We analyzed gut microbiota among 22 virally-suppressed PWH and 12 ECs before and 9-months after randomization to aspirin or atorvastatin. There were no differences in microbiota between PWH and EC at baseline. There was a significant change in beta diversity after aspirin administration, but no difference in microbiota after atorvastatin. These findings suggest that ECs have gut microbiota resembling virally-suppressed PWH, and aspirin but not atorvastatin may impact gut microbiota diversity in PWH.
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Authors Mia Marotti, Brian P. Epling, Angelina G. Angelova, Elisha Segrist, Elizabeth Laidlaw, April Poole, Maura M. Manion, Stephen A. Migueles, Jason V. Baker, Irini Sereti
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Journal The Journal of infectious diseases
Year 2026
DOI
10.1093/infdis/jiag508
URL
https://doi.org/10.1093/infdis/jiag508
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