GABAergic inhibition of the nucleus reuniens stabilizes post-learning quiet states and enhances memory consolidation

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ID: 331966
2026
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Abstract
Abstract Quiet states provide a permissive context for processes that benefit from reduced engagement with the environment, such as memory consolidation, but the circuit mechanisms that stabilize these states remain unclear. The midline thalamic nucleus reuniens (RE) regulates hippocampal-cortical interactions during memory consolidation, but its role in stabilizing post-learning quiet states is unknown. Here, we tested the effects of RE inhibition on quiet-state stability and memory consolidation in freely behaving rats. Following object-place recognition training, rats received RE microinfusions of muscimol or vehicle and we monitored their behavior during the subsequent period. We found that RE inhibition increased the duration of quiet bouts and reduced bout fragmentation. Twenty-four hours later, muscimol-treated rats showed enhanced object-place recognition memory. These findings suggest that RE regulates the stability of quiet states that facilitate memory consolidation and provide a circuit mechanism linking thalamic inhibition, quiet states, and memory function.
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openalex_W7221142807 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Luis M Guemarez, Gabriela Rico, Annie da Costa Souza, Carmen Varela
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Journal SLEEP Advances
Year 2026
DOI
10.1093/sleepadvances/zpag108
URL
https://doi.org/10.1093/sleepadvances/zpag108
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