FP4.5 3D-Printed Polydopamine-Polyurethane Scaffold in a Porcine Model Contributes to Chondral Regeneration in Acetabular Labrum Reconstruction

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ID: 331392
2026
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Abstract
Abstract ICLA04 - The Labral Repair Blueprint: Mastering Anchorage, Suture Loops, and Everyday Success, Auditorium B (BMCC Level 1), October 8, 2026, 10:30 - 12:30 Purpose This study aimed to validate the efficacy of 3D-printed polyurethane/polydopamine (PUDA) scaffolds for acetabular labrum reconstruction. Methods PUDA scaffolds were successfully prepared and characterized using scanning electron microscopy (SEM). An acetabular labrum reconstruction model was established by implanting the grafts into eighteen porcine hips. Hips were collected at 3/6 months post surgery for MRI, gross view and histological evaluation, including hematoxylin and eosin (H&E), Safranin O/fast green (SO/FG), Toluidine blue (TB), immunohistochemistry (Collagen II, COL II), IF (SRY-box9, SOX9; aggrecan, ACAN). Results The polyurethane scaffolds successfully modified with polydopamine. Macroscopic evaluation demonstrated a significantly higher Outbridge score for the regenerated labrum in the PUDA group. Histological staining indicated that the regenerated labrum reconstructed with PUDA adhered to the acetabular rim, with increased deposition of proteoglycan (25.14±5.80%) and elevated expression of COL II (0.05±0.02), SOX9 (25.36±3.61%), and ACAN (21.11±5.01%) compared with control group (labral resection). Conclusions PUDA scaffolds successfully promoted proteoglycan deposition, chondrogenesis, and labrum regeneration, demonstrating chondroprotective effect on the femoral head. Clinical Relevance The polyurethane/polydopamine scaffolds could represent a feasible treatment option for patients with irreparable labra in clinical practice. Key terms Acetabular labrum reconstruction, 3D printing, polyurethane, hip labrum, porcine model
Reference Key
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Authors Cancan Du, Yan Xu
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Journal Journal of hip preservation surgery
Year 2026
DOI
10.1093/jhps/hnag043.029
URL
https://doi.org/10.1093/jhps/hnag043.029
Keywords Keywords not found

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