EP8.11 Effects of Losartan And NSAids On Arthroscopic Hip Surgery

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ID: 331051
2026
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Abstract
Abstract Background Arthroscopic hip surgery has become the standard of care for femoroacetabular impingement (FAI) and labral tears. However, postoperative complications like heterotopic ossification (HO) and intra-articular adhesions can negatively affect patient outcomes. While non-steroidal anti-inflammatories (NSAIDs) are routinely prescribed to manage pain and prevent HO, they may not address fibrosis and intra-capsular adhesions. Losartan, an angiotensin II receptor blocker (ARB), has demonstrated anti-fibrotic and regenerative properties in preclinical trials and may have potential prophylactic use. Objectives This study evaluates whether adding losartan to standard NSAID therapy improves short-term patient-reported outcomes following hip arthroscopy. This hypothesis has not yet been tested clinically. Methods A retrospective cohort analysis was conducted using the UK Non-Arthroplasty Hip Registry (NAHR). Adults undergoing hip arthroscopy were grouped by postoperative medication: losartan + NSAID, NSAID only, or no medication. Outcomes were assessed using the International Hip Outcome Tool-12 (iHOT-12) preoperatively and at 6 and 12 months postoperatively. Propensity score weighting and linear mixed-effects models were used to compare outcomes over time, adjusting for baseline covariates. Results A total of 697 patients were included (losartan + NSAID: 43; NSAID only: 189; no medication: 465). All groups showed significant improvement in iHOT-12 scores over time (p < 0.001), but there were no significant differences between groups over time and no treatment-by-time interaction. Conclusion The addition of losartan to standard NSAID therapy was not associated with improved short-term iHOT-12 outcomes following hip arthroscopy. Longer-term follow-up is needed to assess potential effects on fibrosis, adhesions, and revision rates.
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Authors Aiden Bayliffe, Richard Holleyman, N. Parnis, Ajay Malviya, Tony Andrade
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Journal Journal of hip preservation surgery
Year 2026
DOI
10.1093/jhps/hnag043.392
URL
https://doi.org/10.1093/jhps/hnag043.392
Keywords Keywords not found

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