EP3.13 Femoroacetabular Impingement Rabbit Model Induced by Exercise and Mechanical Stimulation

Clicks: 8
ID: 331026
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Popular

Ranked #406 of 444 articles by views in Journal of hip preservation surgery

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 444 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Background Femoroacetabular impingement (FAI) is one of the major causes of hip pain. Currently, the pathogenesis of FAI remains unclear. There are limited animal models available for studying its pathogenic mechanisms. Purpose This study was performed to evaluate bone deformity formation, labrum and articular cartilage injury induced by mechanical and exercise stimulation and to establish a FAI model in New Zealand white rabbits. Study Design Controlled laboratory study. Methods 6M (6-month-old) and 1M (1-month-old) male rabbits were used. Three-dimensional printed polylactic acid (PLA) scaffolds were surgically fixed to the acetabular rim, followed by postoperative treadmill training. Specimens were collected at 8 and 12 weeks. Bone deformities were assessed by micro-computed tomography (micro-CT). Histological evaluation included hematoxylin and eosin (H&E) staining for morphology, Safranin O/Fast Green (SO/FG) and toluidine blue staining for proteoglycan and glycosaminoglycan deposition, and immunofluorescence for SRY-box transcription factor 9 (SOX9), aggrecan (ACAN), runt-related transcription factor 2 (RUNX2), and cluster of differentiation 31 (CD31) expression. Mechanical properties of the labrum and cartilage were evaluated by nanoindentation, with Young’s modulus as the stiffness parameter. Results Gross evaluation (Ctrl vs FAI, 6M: P<0.0001, 1M: P<0.0001) and micro-CT revealed significant bone deformities and cartilage damage in FAI group. SO/FG staining showed reduced proteoglycan deposition (Ctrl vs FAI, 6M: P=0.0001, 1M: P=0.0006), accompanied by decreased SOX9 (Sham vs FAI, 6M: P<0.0001, 1M: P<0.0001), ACAN (Sham vs FAI, 6M: P=0.0392, 1M: P<0.0001) expression and increased RUNX2 (Sham vs FAI, 6M: P=0.0007, 1M: P=0.0014), CD31 (Sham vs FAI, 6M: P=0.0018, 1M: P=0.0071) expression. Young’s modulus of both the labrum (Ctrl vs FAI, 6M: P<0.0001, 1M: P=0.0061) and femoral head cartilage was reduced. Conclusion A stable, reproducible, and easily operable rabbit model of FAI was established using combined mechanical and exercise stimulation, providing a practical platform for investigating the pathogenesis of FAI. Clinical Relevance FAI animal models established through acetabular overcoverage surgery are expected to provide an effective tool for subsequent research into the pathogenesis of FAI, thereby laying a theoretical foundation for its early targeted treatment. Key Terms Femoroacetabular impingement (FAI), Mechanical stimulation, Exercise stimulation, Pincer FAI model, Age-related injury
Reference Key
openalex_W7220385655 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Cancan Du, Yan Xu
Are you one of these authors? Claim your profile
Journal Journal of hip preservation surgery
Year 2026
DOI
10.1093/jhps/hnag043.298
URL
https://doi.org/10.1093/jhps/hnag043.298
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.