ASSOCIATION BETWEEN PRE- AND POST-INTERVENTION PULMONARY FUNCTION MEASURED BY SPIROMETRY IN PATIENTS WITH LEFT-TO-RIGHT SHUNT CONGENITAL HEART DISEASE

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ID: 331014
2026
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Ranked #319 of 330 articles by views in European heart journal supplements : journal of the European Society of Cardiology

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Abstract
Abstract Background and Aims Acyanotic congenital heart disease (CHD) is the most common birth defect worldwide and is associated with high mortality rate. Heart defects have been known to affect lung volume and function. Patients with spirometry results showing lower-than-predicted FVC and FEV1 are significantly associated with increased incidence of cardiovascular death. This study aims to investigate changes in pulmonary function in patients with acyanotic left-to-right shunt CHD before and after surgical or nonsurgical intervention. Methods This is a cross-sectional study, involving 24 patients with acyanotic left-to-right shunt CHD aged >6 years with diagnosis of atrial septal defect (ASD), ventricular septal defect (VSD) and patent ductus arteriosus (PDA) who were scheduled for surgical or nonsurgical intervention. Pulmonary function was measured before and after the intervention, and bivariate analysis was performed to determine changes in pulmonary function in patients with acyanotic left-to-right shunt CHD before and after the intervention. Results Pulmonary function parameters in acyanotic left-to-right shunt CHD showed a significant improvement in FEV1 after intervention (from 1.51 to 1.67; p=0.047). In the nonsurgical intervention group, there were significant improvements in lung function after intervention compared to before intervention in FVC parameters (from 1.53 to 2.28; p=0.005) and FEV1 (from 1.51 to 1.81; p=0.008). Conclusion There was a significant improvement in FEV1 in patients with acyanotic left-to-right shunt CHD after surgical or non-surgical interventions. Significant improvement in FVC and FEV1 was found in patients with acyanotic left-to-right shunt CHD after nonsurgical intervention compared with after surgical intervention.Table 1a.Pulmonary Function Parameters Before and After Intervention in Patients with Acyanotic CHD with Left-to-Right Shunt, 1b. Pulmonary Function Parameters Before and After Intervention Based on Intervention Category
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openalex_W7220382016 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors
Journal European heart journal supplements : journal of the European Society of Cardiology
Year 2026
DOI
10.1093/eurheartjsupp/suag119.019
URL
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