FP8.3 Development and preclinical validation of a synthetic graft for hip acetabular labrum reconstruction

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ID: 330937
2026
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Abstract
Abstract ICLA08 - AI and 3D Simulations: Trustworthy Clinical Partners or Tech Hype?, Auditorium B (BMCC Level 1), October 8, 2026, 14:00 - 16:00 Introduction Femoroacetabular impingement (FAI) is a common cause of hip pain. FAI plays a prominent role in the pathogenesis of HOA, especially in young adults, leading to chondral damage and labral degeneration. In the last decade the focus has moved to the importance of preserving the labrum through an arthroscopic repair or, if it is not possible, a reconstruction of the labrum represent a valid and effective choice. The aim of this study is to create and test a synthetic graft with an anatomical profile to restore the biomechanical function of the labrum, ready to be used in surgical room in a one-step procedure for a more effective and rapid surgical technique. Methods The graft design was iteratively refined, based on the anatomy of the structures observed from intact tissue samples taken from THR patients. The graft was molded with an FDA and CE-approved silicone (VK100, BONWRx, Lansing, USA). To test the implantability of the graft arthroscopically, and to optimize the procedure, cadaver labs were first performed. To test the strength of the reconstruction under cyclic loading, n=4 composite hemipelves subjected to biomechanical testing (10’000 cycles, with up to 5.0mm imposed deflection). The VK100 cytocompatibility was tested up to 14 days in direct contact with an immortalized chondrocytes human cell line (C-28/I2). Results During the procedure on cadaver, the final prototype showed significant ductility and suitability for arthroscopic implantation, without damage or structural compromise during fixation to the acetabular bone via knotted all suture anchors. All the labrum reconstructions on composite hemipelvises withstood the cyclic test with no sign of damage, despite the large cyclic deformation imposed. C-28/I2 cells were adherent to the VK100 surface with the formation of cell protrusions and filaments from day 1 to later timepoints. Concerning cell cytotoxicity, C-28/I2 cells showed the highest level of toxicity after 1 day from the seeding. After 7 days of culture, no sign of cell death was detected. At 14 days, a slightly increased value of cell stress was observed due to the high cell confluence. Conclusion Our study represents a proof of concept to develop a bioartificial labrum as a new strategy to support surgeons during labrum reconstruction surgery.
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Authors Enrico Tassinari, MD Irene Tampieri, MD Andrea Burla, MD Francesco Aparo, Luca Vigliaroli, Mauro Petretta, Giorgia Borciani, Luca Crisfolini, Stefano Zaffagnini, Eleonora Olivotto
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Journal Journal of hip preservation surgery
Year 2026
DOI
10.1093/jhps/hnag043.059
URL
https://doi.org/10.1093/jhps/hnag043.059
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