Balance of non–Lp(a) apoB and Lp(a) with Coronary Plaque Phenotypes and MACE: Insights from PROSPECT II and CASABLANCA
Clicks: 14
ID: 329860
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Emerging Content
3.9
/100
14 views
13 readers
AI Quality Assessment
Not analyzed
Readership in this journal
EmergingRanked #130 of 246 articles by views in european journal of preventive cardiology
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 246 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Abstract Aims Apolipoprotein B (apoB)-containing lipoproteins contribute heterogeneously to atherosclerosis. While apoB particles are major determinants of plaque burden, Lp(a) has been linked to plaque inflammation and instability. We investigated the associations of non–Lp(a) apoB, Lp(a), and their relative balance with coronary plaque burden and vulnerability. Methods and results Among 854 patients with recent myocardial infarction enrolled in the PROSPECT II near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) study, total apoB was converted to nmol/L and non–Lp(a) apoB calculated by subtracting Lp(a) in nmol/L. The non–Lp(a) apoB/Lp(a) ratio was used to characterize the relative predominance of these lipoprotein classes. Higher non–Lp(a) apoB was independently associated with greater plaque burden (plaque percentage volume; β = 0.19, 95% confidence interval [CI] 0.05-0.33; P = 0.009), but not with lipid core burden index. In contrast, lower non–Lp(a) apoB/Lp(a) ratio tertile were associated with higher odds of plaque burden ≥70% (odds ratio [OR] 1.47, 95% CI 1.04-2.07; P = 0.029) and the composite vulnerability endpoint of plaque burden ≥70% and maxLCBI4mm ≥324.7 (OR 1.62, 95% CI 1.12-2.33; P = 0.011). In an exploratory external cohort from the CASABLANCA study, lower ratios identified an Lp(a)- and oxidized phospholipid-enriched phenotype and were associated with higher unadjusted cardiovascular risk. Conclusions Non–Lp(a) apoB and Lp(a) demonstrate distinct associations with coronary plaque burden and vulnerability. Differentiating Lp(a)-associated from non–Lp(a)-associated apoB particle pools provides complementary information on coronary plaque phenotype, and the non–Lp(a) apoB/Lp(a) ratio summarizes their relative predominance.
| Reference Key |
openalex_W7214468793
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Sotirios Tsimikas, James Louis Januzzi, Michael Mæng, Thomas Engstrøm, Lars Kjøller‐Hansen, Ori Ben‐Yehuda, Mitsuaki Matsumura, Hans Erik Bøtker, Ole Fröbert, Jonas Persson, Rune Wiseth, Alf Inge Larsen, Lisette Okkels Jensen, Jan Erik Nordrehaug, Øyvind Bleie, Elmir Ömerovic, Claes Held, Rebecca Tremain Rylance, Yuxi Liu, Stefan Karl James, Ziad A. Ali, Akiko Maehara, Gregg W. Stone, David Erlinge |
| Journal | european journal of preventive cardiology |
| Year | 2026 |
| DOI |
10.1093/eurjpc/zwag512
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.