O-GlcNAcylation in Macrophage Functions

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ID: 329724
2026
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Abstract
Macrophages are central effectors of the immune system. These cells exhibit a wide range of functions, including inflammation, phagocytosis, antigen presentation, cytokine secretion, and tissue repair, all of which are tightly coupled to their metabolic state. O-GlcNAcylation, a reversible post-translational modification catalyzed exclusively by OGT and OGA, integrates glucose flux through the hexosamine biosynthetic pathway with the regulation of key immune mechanisms. This review evaluates the effect of O-GlcNAcylation on the expression and localization of pattern recognition receptors, endosome maturation, phagocytic capacity, reactive oxygen species production, and pro- and anti-inflammatory polarization.
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openalex_W7214289277 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors José Luis Sánchez, Alí Pereyra, Wilton Henao, Johana Torres-Barrón, Gustavo Ortiz-Chavez, Eleazar Ramírez, Edgar Zenteno Galindo
Journal glycobiology
Year 2026
DOI
10.1093/glycob/cwag084
URL
https://doi.org/10.1093/glycob/cwag084
Keywords Keywords not found

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