Brief exposure to hyperoxia is associated with reduced Plasmodium falciparum in vitro tolerance to Dihydroartemisinin

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ID: 329653
2026
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Abstract
Abstract The ring-stage survival assay (RSA) is a valuable tool for assessing in vitro Plasmodium falciparum tolerance to Dihydroartemisinin. However, laboratories with unreliable or no access to premixed commercial gas may not perform the RSA under the recommended physiological normoxia. We measured survival rates of ART-sensitive and ART-resistant strains in the normoxic commercial gas and hyperoxic candle jar gas. RSA read-outs for ART-resistant strains were significantly lower (p<0.05) under hyperoxia compared to physiological normoxia, whereas those of ART-sensitive strains were unaltered. These findings have important implications for interlaboratory comparison of RSA data and understanding the mechanisms of resistance to endoperoxide drugs.
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openalex_W7214160715 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Standwell C. Nkhoma, Amel O A Ahmed, Sujatha Rashid, Robert E. Molestina
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Journal The Journal of infectious diseases
Year 2026
DOI
10.1093/infdis/jiag490
URL
https://doi.org/10.1093/infdis/jiag490
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