External validation of the PACTO risk score for infective endocarditis in patients with coagulase-negative staphylococcal bacteremia: a multicenter cohort study

Clicks: 28
ID: 329553
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #73 of 318 articles by views in Open forum infectious diseases

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 318 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Background Coagulase-negative staphylococci (CoNS) are a leading cause of prosthetic-valve infective endocarditis (IE) and an emerging cause of native-valve IE. Identifying patients with CoNS bacteremia at high risk of IE remains a significant clinical challenge. The PACTO score, derived from a single-center cohort, integrates four early-available predictors of IE. Methods We conducted a multicenter retrospective cohort study of 302 adults with true CoNS bacteremia who underwent echocardiography at several Spanish hospitals between October 2016 and September 2025. IE was diagnosed according to the 2023 Duke-ISCVID criteria. The PACTO score assigns points for prosthetic valve or pacemaker (4), all blood culture bottles positive (2), community-acquired bacteremia (2), and continuous bacteremia (positive cultures 12–72 hours apart; 1). Results Definite IE was diagnosed in 60 patients (19.9%). The PACTO score showed excellent discrimination (AUC 0.828; 95% CI 0.773–0.883) and good calibration (Hosmer-Lemeshow p=0.360). IE prevalence increased progressively across risk categories, from 1.6% (0–1 points) to 84.6% (>7 points). A score <2 points yielded a negative predictive value of 98.4% (sensitivity 98.3%). Conclusions This multicenter external validation demonstrates that the PACTO score provides robust risk stratification for IE in patients with CoNS bacteremia, supporting safe deferral of echocardiography in low-risk patients and prompt imaging in high-risk individuals. Prospective validation is warranted.
Reference Key
openalex_W7214068697 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors António Ramos, Itziar Yagüe-Diego, Luis Eduardo López-Cortés, María Sánchez Ledesma, Carmen Sáez-Béjar, Carmen Hidalgo-Tenorio, Marta Murga de la Fuente, Jesús Rodríguez‐Baño, David Puertas-Miranda, Benedetta Varisco, Marianela Ciudad-Sañudo, Inmaculada López-Hernández, Jorge Calderón-Parra
Are you one of these authors? Claim your profile
Journal Open forum infectious diseases
Year 2026
DOI
10.1093/ofid/ofag599
URL
https://doi.org/10.1093/ofid/ofag599
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.