Hazy mysteries and the major histocompatibility complex: a journey

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ID: 329450
2026
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Abstract
I was pleased to receive an invitation to write a historical perspective on my career. As I understand it, these perspectives aim to illustrate the often-twisted paths to discoveries, the fortuitous events that often enable them, and the pitfalls along the way. At the same time, they can be expected to illustrate the influence of the particular 'tastes' and interests of a scientist in the choices that are made along the way and that there are many ways to position oneself in a field of study. This article describes my initial interest in molecular biology, the early events that led me to undertake graduate studies in cellular immunology with a focus on MHC restriction of T cell specificity and T cell activation, and the serendipitous events that led to my eventual transition to a focus on natural killer cells and cancer immunotherapy. I hope that this piece provides some of the illustrations mentioned and will therefore be of interest to a range of readers with an interest in immunology research.
Reference Key
openalex_W7214000038 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors David H. Raulet
Journal journal of leukocyte biology
Year 2026
DOI
10.1093/jleuko/qiag129
URL
https://doi.org/10.1093/jleuko/qiag129
Keywords Keywords not found

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