The Clinical Significance of Streptococcus mitis bacteremia

Clicks: 12
ID: 329375
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #284 of 316 articles by views in Open forum infectious diseases

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 316 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Introduction Except for their role in bacterial endocarditis, non-pneumococcal Streptococcus mitis group (SMG) bacteria have traditionally been regarded as commensals of the oropharynx. Widespread adoption of matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry has increased identification of these organisms and has led to increased concern about their clinical significance. We evaluated SMG bacteremia in a large multicenter cohort to characterize associated clinical syndromes and better define their clinical relevance. Methods We performed a retrospective review of all adult patients from 2017 to 2025 who had SMG bacteremia at three hospitals within the Texas Medical Center. SMG bacteremia was defined as isolation of S. mitis, S. mitis/oralis, or S. mitis group as determined by MALDI-TOF. Clinical syndromes were identified through chart review and assigned using consistent classification approaches informed by physician documentation, imaging, and microbiologic data. Results Among 253 patients, neutropenia-associated bacteremia was most common (29.6%) followed by pneumonia (9.5%), infective endocarditis (8.7%), skin, soft tissue, or bone infections (7.9%), and other identified sources (12%). No clear source was identified in 9.5% of cases. Only 22.9% were classified as contaminants. High-grade bacteremia was common, with 47% of cases having ≥ 3 positive blood culture bottles. In contrast, patients in whom SMG was regarded as contaminant nearly always had only a single bottle positive. Conclusion SMG bacteremia was associated with a broad spectrum of clinical syndromes, with most isolates being regarded as representing clinically significant infection.
Reference Key
openalex_W7213981368 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors James Howard Acuff, Erin H. Yang, Ananth Panchamukhi, Kenneth L. Muldrew, Robert L. Atmar, Daniel M. Musher
Are you one of these authors? Claim your profile
Journal Open forum infectious diseases
Year 2026
DOI
10.1093/ofid/ofag588
URL
https://doi.org/10.1093/ofid/ofag588
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.