Polyamines, cardiorespiratory fitness, body composition, and mitochondrial function in older patients with coronary artery disease

Clicks: 8
ID: 329371
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #73 of 80 articles by views in European Heart Journal Open

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Aims Higher dietary spermidine intake has been associated with lower cardiovascular mortality. Spermidine and spermine support cellular homeostasis and mitochondrial function across species, but their relevance to physical and mitochondrial function in humans remains unclear. We examined associations of dietary spermidine and circulating and skeletal muscle spermidine and spermine with physical performance, body composition, and mitochondrial respiratory capacity in older patients with coronary artery disease. Methods and results We included 187 patients with coronary artery disease (median age 72 [68-76] years; 80% men; 95% with prior coronary revascularisation). The primary outcomes were peak oxygen uptake and appendicular lean mass. Each doubling of dietary spermidine intake was associated with higher peak oxygen uptake (β 2.6 mL·kg−1·min−1, 95% CI 0.9-4.4; P = 0.003). This association remained after adjustment for age, sex, and physical activity. Dietary spermidine intake was also associated with higher appendicular lean mass, but this association was attenuated after adjustment. Among secondary outcomes, higher spermidine intake was associated with higher appendicular lean mass/body mass index and lower body fat percentage. In a subgroup, higher spermidine intake was associated with greater mitochondrial respiration. In exploratory analyses, a higher skeletal muscle spermine-to-spermidine ratio showed similar associations (all P ≤ 0.035). Conclusion These observational findings warrant randomised trials to determine whether dietary spermidine interventions may influence physical and mitochondrial function in older patients with coronary artery disease.
Reference Key
openalex_W7213974585 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Christian Velling Thorup, Thomas Jensen, Chris Nørgaard Agerbo Jeppesen, Andreas Bugge Tinggaard, Mogens Johannsen, Jakob Hansen, Christian Lodberg Hvas, Charlotte Lock Rud, Roni Ranghoej Nielsen, Jakob Wang, Jean Farup, Niels Jessen, Henrik Wiggers
Are you one of these authors? Claim your profile
Journal European Heart Journal Open
Year 2026
DOI
10.1093/ehjopen/oeag150
URL
https://doi.org/10.1093/ehjopen/oeag150
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.