Impact of Differences in Kidney Function Estimation by Creatinine compared to Cystatin C on Clinical Outcomes in Patients with Atrial Fibrillation

Clicks: 7
ID: 329295
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #76 of 80 articles by views in European Heart Journal Open

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Background and Aims Differences between cystatin C-based and creatinine-based glomerular filtration rate estimations (eGFRdiff) have been associated with adverse outcomes. We aimed to investigate the prevalence of eGFRdiff and its association with clinical outcomes and brain lesions in patients with AF. Methods We analyzed 3,804 patients with AF enrolled in two prospective, multicenter cohort studies. The eGFRdiff was calculated by “cystatin C-based eGFR - creatinine-based eGFR”. Patients were stratified into three groups: eGFRdiff >10, -10 to 10, and <-10 mL/min/1.73 m2. Associations with high-sensitivity troponin T (hs-TnT), NT-proBNP, major adverse cardiovascular events (stroke/systemic embolism, myocardial infarction and cardiovascular death), first heart failure (HF) hospitalization, and MRI-detected brain lesions were assessed. Results Mean age was 71 years, 28% were female, and 49% had paroxysmal AF. An eGFRdiff of >10, -10 to 10 and <-10 ml/min/1.73 m2 was present in 17.7%, 71.7%, and 10.6% of the patients, respectively. Incidence rates per 100 patient-years increased across these groups for MACE (1.7, 3.9, 6.8) and HF-hospitalization (1.2, 3.5, 6.1). Similarly, the prevalence of MRI-detected brain infarcts (28%, 39%, 42%) and moderate-to-severe white matter hyperintensities (38%, 55%, 63%) increased with greater eGFRdiff. Levels of hs-TnT and NT-proBNP were inversely correlated with eGFRdiff. In multivariable-adjusted linear models, lower eGFRdiff was associated with MACE (p = 0.006) and HF-hospitalization (p = 0.015). Conclusion A substantial proportion of patients with AF exhibit clinically relevant eGFRdiff. More negative eGFR difference was associated with elevated cardiac biomarkers, greater burden of ischemic brain lesions, and increased risk of cardiovascular events and HF hospitalization.
Reference Key
openalex_W7213986985 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Philipp Krisai, Mikko Mutti, Stefanie Aeschbacher, Michael Coslovsky, Tobias Reichlin, Heba Alwan, Peter Ammann, Giorgio Moschovitis, Elia Rigamonti, Giulio Conte, Moa Lina Haller, Amelie Stoecklin, Leo Hermann Bonati, Stefan Osswald, David Conen, Felix Mahfoud, Michael Kühne
Are you one of these authors? Claim your profile
Journal European Heart Journal Open
Year 2026
DOI
10.1093/ehjopen/oeag145
URL
https://doi.org/10.1093/ehjopen/oeag145
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.