The light side of mast cell degranulation: delivering macrophage repair through molecular condensates
Clicks: 1
ID: 328781
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
0.0
/100
1 views
0 readers
AI Quality Assessment
Not analyzed
Readership in this journal
Ranked #93 of 95 articles by views in journal of leukocyte biology
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Mast cell (MC) degranulation is commonly viewed as the rapid release of preformed inflammatory mediators into the extracellular environment. In a recent study published in the Journal of Experimental Medicine, Salm et al. described a more spatially controlled form of MC communication following sterile peritoneal injury. Sensory neurons activated MCs through substance P signaling, promoting the release of extracellular granules that persisted as membraneless biomolecular condensates. These condensates, enriched in more than 200 proteins, remained associated with the surface of large peritoneal macrophages (LPMs), where they contributed to rapid macrophage aggregation through the scavenger receptor MARCO and promoted a repair-like phenotype at the injury site. Lattice light sheet microscopy further revealed F-actin-containing cytonemes that captured condensates from the MC surface and distributed them to surrounding macrophages. Importantly, disruption of this process impaired condensate dispersion, LPM recruitment, and wound healing. The study expands the conventional view of MC degranulation beyond the release of inflammatory soluble mediators by showing that released granules can remain organized and be actively positioned within injured tissue, creating a localized communication system between sensory neurons, MCs, and macrophages.
| Reference Key |
openalex_W7213251754
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Alejandro Schcolnik‐Cabrera, Rommel Chacón‐Salinas |
| Journal | journal of leukocyte biology |
| Year | 2026 |
| DOI |
10.1093/jleuko/qiag125
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.