Differences in retroactive interference response reveal sex-specific memory resilience in pre-symptomatic triple transgenic Alzheimer’s disease mice

Clicks: 17
ID: 328519
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #130 of 196 articles by views in Brain communications

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 196 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Alzheimer’s disease is a neurodegenerative disorder characterized by memory loss dependent on hippocampal and parahippocampal cortex dysfunction. However, recent evidence shows that patients with mild cognitive impairment progressing to Alzheimer’s disease can exhibit early symptoms when assessed with more nuanced memory tests, such as those evaluating memory vulnerability to interference. Here, we characterize how sex and genotype shape the response to retroactive interference in triple transgenic Alzheimer’s disease mice at an early stage of the phenotype, when overt memory deficits are not yet present. Wild-type females were the only group resisting interference: transgenic females failed to discriminate despite normal recognition memory, irrespective of the moment during which retroactive interference was experienced, and males of both genotypes were similarly impaired at every time point tested. Both context change and increased memory strength restored discrimination in transgenic females and wild-type males, suggesting that their susceptibility depends on overlapping hippocampal representations. Transgenic males, by contrast, remained impaired when interference occurred in a different context and showed only a limited improvement after multiple training, pointing to a larger contribution of interference-induced memory decay. Overall, our data characterize the response to retroactive interference as a sex-dependent behavioural readout of early memory instability in a preclinical model of Alzheimer’s disease.
Reference Key
openalex_W7212271016 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Chiara D'Amelio, Sara Autelitano, Francesca Natale, Marco Rinaudo, Salvatore Fusco, Claudio Grassi
Are you one of these authors? Claim your profile
Journal Brain communications
Year 2026
DOI
10.1093/braincomms/fcag345
URL
https://doi.org/10.1093/braincomms/fcag345
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.