Metabolic Changes in Pediatric HIV Patients on Contemporary Antiretroviral Therapy: Implications for Research and Interventions

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ID: 328371
2026
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Abstract
Despite advances in antiretroviral therapy, children living with HIV remain at increased risk for early cardiometabolic disease. Although second-generation integrase strand transfer inhibitors such as dolutegravir (DTG) have been associated with weight gain in adults, pediatric clinical trials have demonstrated a largely weight-neutral metabolic profile. Emerging observational data, however, report excess DTG-associated weight gain among children and adolescents living in increasingly obesogenic environments. As pediatric HIV epidemiology shifts from undernutrition toward a growing burden of obesity, HIV care should incorporate longitudinal metabolic monitoring, nutritional counseling, and continued research on the long-term cardiometabolic effects of DTG.
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openalex_W7212404694 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Caroline Carlson, Sahera Dirajlal‐Fargo
Journal journal of the pediatric infectious diseases society
Year 2026
DOI
10.1093/jpids/piag097
URL
https://doi.org/10.1093/jpids/piag097
Keywords Keywords not found

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