Metabolic Changes in Pediatric HIV Patients on Contemporary Antiretroviral Therapy: Implications for Research and Interventions

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ID: 328371
2026
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Abstract
Despite advances in antiretroviral therapy, children living with HIV remain at increased risk for early cardiometabolic disease. Although second-generation integrase strand transfer inhibitors such as dolutegravir (DTG) have been associated with weight gain in adults, pediatric clinical trials have demonstrated a largely weight-neutral metabolic profile. Emerging observational data, however, report excess DTG-associated weight gain among children and adolescents living in increasingly obesogenic environments. As pediatric HIV epidemiology shifts from undernutrition toward a growing burden of obesity, HIV care should incorporate longitudinal metabolic monitoring, nutritional counseling, and continued research on the long-term cardiometabolic effects of DTG.
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Authors Caroline Carlson, Sahera Dirajlal‐Fargo
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Journal journal of the pediatric infectious diseases society
Year 2026
DOI
10.1093/jpids/piag097
URL
https://doi.org/10.1093/jpids/piag097
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