Mitral annulus calcification and the risk of infective endocarditis: Insights from DANCAVAS screening Trials

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ID: 327913
2026
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Abstract
Abstract Aims Risk stratification in infective endocarditis (IE) does not incorporate structural substrates involved in early disease initiation. The aim of this study was to examine the association between mitral annulus calcification (MAC) burden and the risk of IE. Methods This substudy utilized the population-based DANCAVAS cohort undergoing non-contrast computed tomography (CT) with MAC quantification with follow-up until August 19, 2025. The primary outcome was incidence rates and 10-year risk of IE across three exploratory categorical groups: No MAC (0 arbitrary units (AU)), MAC 1-299 AU, and MAC ≥300 AU. Results A total of 14,793 participants were included with mean (SD) age, 66.9 (3.8) years, and 14,053 males (95.0%). Median MAC was 13 AU (IQR3.3-56.2) in the MAC 1-299 group and 680 AU (IQR447-1,271) in the MAC ≥300 group. IE incidence rate per 10,000 person-years was 1.92 for no MAC, 2.48 for MAC 1-299, and 21.3 for MAC ≥300 (p < 0.001). The 10-year cumulative risk was, 0.20%(95%CI 0.12-0.33) for no MAC, 0.22% (95%CI 0.10-0.49) for MAC 1-299, and 1.85% (95%CI 0.93-3.69) for MAC ≥300 (p < 0.001). Each 100 AU increase in MAC was associated with a 3% increase in the risk of IE (HR 1.03, 95%CI 1.01-1.05, p = 0.011). MAC ≥300 AU remained associated with IE after adjustment for established risk factors (HR 7.05, 95%CI 2.85 to 17.4, p < 0.001). Conclusion Greater MAC burden was associated with a higher risk of IE. In exploratory categorical analyses, MAC ≥300 AU was associated with the highest observed risk, although these findings should be interpreted with caution given the limited number of events. Funding No specific grant from any funding agency in the public, commercial, or not-for-profit sectors was received for this research.
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Authors Lytfi Krasniqi, Axel Cosmus Pyndt Diederichsen, Jes S. Lindholt, Camilla Engelsgaard, Martin Busk, Lars Frost, Jess Lambrechtsen, Marek Karon, Jordi S. Dahl
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Journal European Heart Journal Open
Year 2026
DOI
10.1093/ehjopen/oeag140
URL
https://doi.org/10.1093/ehjopen/oeag140
Keywords Keywords not found

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