A case report of MINOCA Caused by Severe Myocardial Bridging: Insights from Resting Full-Cycle Ratio and Perfusion Imaging

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ID: 327806
2026
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Abstract
Abstract Background Myocardial bridging (MB) is often considered a benign anatomical variant, yet deep or long bridges can result in dynamic coronary compression and ischemia. In rare instances, MB may lead to myocardial infarction with nonobstructive coronary arteries (MINOCA), posing a diagnostic challenge. Case summary We report the case of a 59-year-old man who presented with chest pain and elevated cardiac troponin following exertion. Coronary angiography showed no obstructive coronary artery disease but revealed a myocardial bridge in the mid-left anterior descending (LAD) artery with complete systolic compression. Intravascular ultrasound (IVUS) confirmed the presence of MB without underlying atherosclerosis. Functional assessment using resting full-cycle ratio (RFR) demonstrated a value of 0.91. Single-photon emission computed tomography (SPECT) revealed no perfusion defects, supporting the absence of significant ischemia. The patient was diagnosed with MINOCA secondary to myocardial bridging and treated conservatively with beta-blockers. He remained free of recurrent myocardial infarction and the exertional chest pain was markedly improved. Discussion This case highlights the potential of severe MB to cause infarction in the absence of fixed coronary lesions. It also underscores the diagnostic utility of RFR in assessing MB physiology and its concordance with perfusion imaging.
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openalex_W7211942070 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors
Journal European Heart Journal - Case Reports
Year 2026
DOI
10.1093/ehjcr/ytag673
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